The sudden aerial invasion of Earth by ＜Aliens＞ and their creations ＜Machine Lifeforms＞ led mankind to the brink of extinction. The surviving number of humans who took refuge on the moon to organize a counterattack using ＜android＞ soldiers to recapture Earth.

However, the war reaches a stalemate as the ＜Machine Lifeforms＞ continue to multiply infinitely. In turn, humanity deploys anew unit of android soldiers as an ultimate weapon: ＜YoRHa＞

Newly dispatched to Earth ＜2B＞ joins ＜9S＞, the analyst currently stationed there, where amid their mission, they encounter a myriad of mysterious phenomena…

This is the story of these lifeless ＜androids＞ and their endless fight for the sake of mankind.